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Sasanka Ramanadham Selected Research

Calcium-Independent Phospholipases A2

12/2012Role of calcium-independent phospholipase A(2)β in human pancreatic islet β-cell apoptosis.
5/2010Evidence for proteolytic processing and stimulated organelle redistribution of iPLA(2)beta.
2/2010Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1.
12/2008Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis.
9/2007The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase.
7/2006Insulin secretory responses and phospholipid composition of pancreatic islets from mice that do not express Group VIA phospholipase A2 and effects of metabolic stress on glucose homeostasis.
5/2006Effects of biological oxidants on the catalytic activity and structure of group VIA phospholipase A2.
2/2005Group VIA phospholipase A2 forms a signaling complex with the calcium/calmodulin-dependent protein kinase IIbeta expressed in pancreatic islet beta-cells.
12/2004Characterization of N-terminal processing of group VIA phospholipase A2 and of potential cleavage sites of amyloid precursor protein constructs by automated identification of signature peptides in LC/MS/MS analyses of proteolytic digests.
2/2004Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta.
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Sasanka Ramanadham Research Topics

Disease

13Insulinoma
12/2012 - 04/2002
8Type 1 Diabetes Mellitus (Autoimmune Diabetes)
10/2021 - 09/2012
4Diabetes Mellitus
09/2013 - 02/2004
3Hyperglycemia
03/2008 - 01/2002
2Brain Neoplasms (Brain Tumor)
01/2022 - 01/2020
2Glioblastoma (Glioblastoma Multiforme)
01/2022 - 01/2020
2Autoimmune Diseases (Autoimmune Disease)
11/2020 - 01/2019
2Neoplasms (Cancer)
11/2020 - 01/2020
2Glucose Intolerance
10/2020 - 07/2006
2Mitochondrial Diseases (Mitochondrial Disease)
09/2013 - 12/2008
2Insulin Resistance
05/2010 - 03/2008
2Type 2 Diabetes Mellitus (MODY)
03/2008 - 02/2004
1Nervous System Diseases (Neurological Disorders)
01/2019
1Inflammation (Inflammations)
10/2016
1Infections
05/2010
1Metabolic Syndrome (Dysmetabolic Syndrome X)
03/2008
1Alzheimer Disease (Alzheimer's Disease)
12/2004

Drug/Important Bio-Agent (IBA)

14Calcium-Independent Phospholipases A2IBA
12/2012 - 04/2002
8Insulin (Novolin)FDA Link
09/2013 - 01/2002
6Phospholipases (Phospholipase)IBA
02/2015 - 02/2004
5Glucose (Dextrose)FDA LinkGeneric
10/2020 - 12/2003
5Phospholipases A2 (Phospholipase A2)IBA
01/2019 - 12/2003
4LipidsIBA
01/2020 - 05/2010
3CeramidesIBA
01/2022 - 09/2007
3CytokinesIBA
11/2020 - 03/2008
3Phospholipids (Phosphatides)FDA LinkGeneric
05/2006 - 10/2004
36- (bromomethylene)tetrahydro- 3- (1- naphthaleneyl)- 2H- pyran- 2- oneIBA
02/2005 - 02/2004
2SphingolipidsIBA
10/2021 - 01/2020
2Blood Glucose (Blood Sugar)IBA
09/2013 - 07/2006
2Protein Isoforms (Isoforms)IBA
05/2010 - 12/2003
2HIV Protease InhibitorsIBA
05/2010 - 03/2008
2SphingomyelinsIBA
12/2008 - 09/2007
2Proteins (Proteins, Gene)FDA Link
03/2008 - 12/2004
2ThapsigarginIBA
09/2007 - 02/2004
2CalciumIBA
02/2004 - 02/2004
1Acid CeramidaseIBA
01/2022
1CeramidasesIBA
01/2022
1Hydroxyl RadicalIBA
11/2020
1AcidsIBA
11/2020
1Temozolomide (Temodar)FDA LinkGeneric
01/2020
1Biomarkers (Surrogate Marker)IBA
01/2020
1sphingosine 1-phosphate (sphingosine-1-phosphate)IBA
01/2020
1LysophospholipidsIBA
10/2016
1EicosanoidsIBA
10/2016
1Arachidonic Acid (Vitamin F)IBA
10/2016
1Oxidants (Oxidizing Agents)IBA
09/2013
1Mitochondrial Proteins (Mitochondrial Protein)IBA
09/2013
1Mitochondrial DNA (mtDNA)IBA
09/2013
1RyanodineIBA
09/2012
1Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA
09/2012
1Lipid Bilayers (Lipid Bilayer)IBA
09/2012
1Fatty Acids (Saturated Fatty Acids)IBA
05/2010
1Ritonavir (Norvir)FDA Link
04/2009
1LopinavirFDA Link
04/2009
1Atazanavir Sulfate (Reyataz)FDA Link
04/2009
1tipranavirFDA Link
04/2009
1ColforsinIBA
12/2008
1Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA
09/2007
1Streptozocin (Streptozotocin)FDA Link
07/2006
1Biological ProductsIBA
07/2006
1KN 93IBA
02/2005
1Amyloid (Amyloid Fibrils)IBA
12/2004
1EnzymesIBA
12/2004

Therapy/Procedure

1Drug Therapy (Chemotherapy)
01/2020
1Highly Active Antiretroviral Therapy (HAART)
05/2010
1Therapeutics
05/2010